TM
OUR SCIENCE
Innovation in Immune Tolerance
Pioneering advancements in Longevity, Autoimmunity, Cancer, and Inflammation, SFA Therapeutics is at the forefront of cutting-edge research. Our groundbreaking mechanism of immune modulation effectively resets the immune system, combats oxidative stress, and regulates cellular senescence. With a science-driven approach, we are dedicated to revolutionizing the field immune tolerance, restore immune homeostasis and battle the effects of chronic inflammation.
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​At the cellular level, SFA drugs act through several mechanisms, including the activation of G protein-coupled receptors (GPCRs).
SFA-002 acts as an immunomodulator to maintain immune homeostasis.​
SFA-002 modulates the histone histone deacetylase pathway to increase Treg differentiation, promoting up-regulation of anti-inflammatory IL-10 and Inhibition of several pro-inflammatory cytokines (IL-17, IL-23, TNF-α, and IFN-y)
SFA-002
Cellular Membrane
Pro-Inflammatory
IL-23, IL-17
TNF-α, INF-y
Signaling via Transporters
Signaling via
G-Protein Coupled Receptors
MCTs
SMCTs
Immune Cell Modulation
FFAR2
FFAR3
OR51E2
GPR109A
Anti-Inflammatory
IL-10
SFA-002 in PSORIASIS
LL37/
Self RNA
Regulatory T-Lymphocyte (Anti-Inflammatory)
Dendritic Cell
HDAC
TNF-α
IL-23
SFA002
INF-γ
IL-12
IL-6
IL-1β
IL-6
T-Lymphocyte (Effector)
TNF-R
IL-17R
TNF-α
IL-23
Keratocyte (Skin Cells)
SFA002
SFA002
SFA002
IL-6
TNF-α
IL-1β
IL-22
IL-17A
IL-17F