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OUR SCIENCE
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​At the cellular level, SFA drugs act through several mechanisms, including the activation of G protein-coupled receptors (GPCRs).
SFA-002 acts as an immunomodulator to maintain immune homeostasis.​
SFA-002 suppresses HDACs to increase Treg differentiation, promoting up-regulation of anti-inflammatory IL-10 and Inhibition of several pro-inflammatory cytokines (IL-17, IL-23, TNF-α, and IFN-y)
SFA-002
Cellular Membrane
Pro-Inflammatory
IL-23, IL-17
TNF-α, INF-y
Signaling via Transporters
Signaling via
G-Protein Coupled Receptors
MCTs
SMCTs

Immune Cell Modulation

FFAR2
FFAR3
OR51E2
GPR109A


Anti-Inflammatory
IL-10
SFA-002 in PSORIASIS
LL37/
Self RNA




Regulatory T-Lymphocyte (Anti-Inflammatory)
Dendritic Cell

HDAC
TNF-α
IL-23
SFA002
INF-γ
IL-12
IL-6
IL-1β

IL-6
T-Lymphocyte (Effector)
TNF-R
IL-17R
TNF-α
IL-23
Keratocyte (Skin Cells)
SFA002


SFA002

SFA002

IL-6
TNF-α
IL-1β
IL-22
IL-17A
IL-17F